Lithium orotate consists of lithium, an alkali metal, and orotic acid, a compound produced naturally in the body. This mineral is similar to sodium and iodine. Though its exact mechanism of action in the brain is still unidentified, lithium has been shown in the research to boost neurotransmitter activity, including that of dopamine and serotonin, and to reduce the activity of the excitatory brain chemical glutamate. It also plays a role in the gene expression of natural detoxification enzymes in the brain, including glutathione S-transferase offering important brain antioxidant protection, contributing to better cognitive health and memory. Other research has shown it to increase DHA in the brain, and even to promote cognitive longevity.